Find the best quotes by Francis Crick.
Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet…
If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt…
How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us…
Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but…
The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one…
Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to…
If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we…
We are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put…
It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure…
It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular…
This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on…
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that…
It seems likely that most if not all the genetic information in any organism is carried by nucleic acid – usually by DNA, although certain…
It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in…
It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a…
Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or…
A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein…
A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of…
If poly A is added to poly U, to form a double or triple helix, the combination is inactive.
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